| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50031773 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205626 (CHEMBL812385) |
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| Ki | 9.0±n/a nM |
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| Citation |  Gowravaram, MR; Tomczuk, BE; Johnson, JS; Delecki, D; Cook, ER; Ghose, AK; Mathiowetz, AM; Spurlino, JC; Rubin, B; Smith, DL Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group. J Med Chem38:2570-81 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50031773 |
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| n/a |
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| Name | BDBM50031773 |
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| Synonyms: | (R)-2-[4-(4-Chloro-phenoxy)-butyl]-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-succinamide | CHEMBL421161 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H32ClN3O5 |
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| Mol. Mass. | 441.949 |
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| SMILES | CNC(=O)[C@@H](NC(=O)[C@H](CCCCOc1ccc(Cl)cc1)CC(=O)NO)C(C)(C)C |
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| Structure | 
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