| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
|---|
| Ligand | BDBM50031954 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_36797 (CHEMBL650317) |
|---|
| Ki | 0.45±n/a nM |
|---|
| Citation |  Kiyama, R; Honma, T; Hayashi, K; Ogawa, M; Hara, M; Fujimoto, M; Fujishita, T Novel angiotensin II receptor antagonists. Design, synthesis, and in vitro evaluation of dibenzo[a,d]cycloheptene and dibenzo[b,f]oxepin derivatives. Searching for bioisosteres of biphenylyltetrazole using a three-dimensional search technique. J Med Chem38:2728-41 (1995) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Type-1 angiotensin II receptor |
|---|
| Name: | Type-1 angiotensin II receptor |
|---|
| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41080.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P30556 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
|
|
|
|---|
| BDBM50031954 |
|---|
| n/a |
|---|
| Name | BDBM50031954 |
|---|
| Synonyms: | 3-(2-Cyclopropyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-11-(1H-tetrazol-5-yl)-dibenzo[a,d]cyclohepten-5-one | CHEMBL93522 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H23N7O |
|---|
| Mol. Mass. | 473.5285 |
|---|
| SMILES | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(cc5ccccc5c(=O)c4c3)-c3nnn[nH]3)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
