| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50032362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35416 (CHEMBL643590) |
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| IC50 | 40±n/a nM |
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| Citation |  Quan, ML; Chiu, AT; Ellis, CD; Wong, PC; Wexler, RR; Timmermans, PB Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors. J Med Chem38:2938-45 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41346.62 |
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| Organism: | RAT |
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| Description: | Angiotensin II AT2 0 0::P35351 |
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| Residue: | 363 |
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| Sequence: | MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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| BDBM50032362 |
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| n/a |
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| Name | BDBM50032362 |
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| Synonyms: | 3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid methyl ester | 5-Ethyl-3-(3-fluoro-2'-isopentyloxycarbonylsulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazole-4-carboxylic acid methyl ester(EXP408) | CHEMBL294512 | isopentyloxy 2-{2-[3-flouoro-4-(4-ethyl-5-methyloxycarbonyl-2-propyl-1H-1-imidazolylmethyl)phenyl]phenylsulfonyl}carbonylamino |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36FN3O6S |
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| Mol. Mass. | 573.676 |
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| SMILES | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C |
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| Structure | 
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