Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50033636

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_48594

IC50

42±n/a nM

Citation

Amblard, M; Rodriguez, M; Lignon, MF; Galas, MC; Bernad, N; Artis-Noël, AM; Hauad, L; Laur, J; Califano, JC; Aumelas, A Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3-amino-6-(phenyloxy)hexanoic acid. J Med Chem36:3021-8 (1993) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

48980.43

Organism:

RAT

Description:

Cholecystokinin A CCKBR RAT::P30553

Residue:

452

Sequence:

MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGL
ISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCV
QLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTW
RAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRA
RPQPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50033636

n/a

Name

BDBM50033636

Synonyms:

3-{2-[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-sulfo-phenyl)-propionylamino]-hexanoylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-6-phenoxy-hexanoic acid | CHEMBL385918 | CHEMBL414180

Type

Small organic molecule

Emp. Form.

C51H69N7O13S

Mol. Mass.

1020.198

SMILES

CCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)NC(CCCOc1ccccc1)CC(O)=O

Structure