| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase TEM |
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| Ligand | BDBM50033697 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40710 (CHEMBL653595) |
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| IC50 | >20000±n/a nM |
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| Citation |  Buynak, JD; Wu, K; Bachmann, B; Khasnis, D; Hua, L; Nguyen, HK; Carver, CL Synthesis and biological activity of 7-alkylidenecephems. J Med Chem38:1022-34 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase TEM |
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| Name: | Beta-lactamase TEM |
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| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
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| Type: | Enzyme |
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| Mol. Mass.: | 31512.33 |
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| Organism: | Escherichia coli |
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| Description: | P62593 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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|
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| BDBM50033697 |
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| n/a |
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| Name | BDBM50033697 |
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| Synonyms: | CHEMBL8571 | Sodium; (R)-3-acetoxymethyl-8-oxo-7-[2-oxo-prop-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12NO6S |
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| Mol. Mass. | 310.303 |
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| SMILES | CC(=O)OCC1=C(N2[C@H](SC1)C(=CC(C)=O)C2=O)C([O-])=O |w:12.13,t:5| |
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| Structure | 
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