Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM50034863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_144615 (CHEMBL750543) |
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IC50 | 203±n/a nM |
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Citation | Ksander, GM; Ghai, RD; deJesus, R; Diefenbacher, CG; Yuan, A; Berry, C; Sakane, Y; Trapani, A Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem38:1689-700 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11 |
Type: | Protein |
Mol. Mass.: | 85789.59 |
Organism: | Rattus norvegicus (Rat) |
Description: | P07861 |
Residue: | 750 |
Sequence: | MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW
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BDBM50034863 |
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n/a |
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Name | BDBM50034863 |
Synonyms: | 4-(2-Carboxy-ethylcarbamoyl)-2-(4-phenoxy-benzyl)-5-(4-phenoxy-phenyl)-pentanoic acid | CHEMBL46836 |
Type | Small organic molecule |
Emp. Form. | C34H33NO7 |
Mol. Mass. | 567.6283 |
SMILES | OC(=O)CCNC(=O)C(CC(Cc1ccc(Oc2ccccc2)cc1)C(O)=O)Cc1ccc(Oc2ccccc2)cc1 |
Structure |
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