| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM82258 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_948640 (CHEMBL2345156) |
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| IC50 | 5.6±n/a nM |
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| Citation |  Agelis, G; Resvani, A; Koukoulitsa, C; T?mová, T; Slaninová, J; Kalavrizioti, D; Spyridaki, K; Afantitis, A; Melagraki, G; Siafaka, A; Gkini, E; Megariotis, G; Grdadolnik, SG; Papadopoulos, MG; Vlahakos, D; Maragoudakis, M; Liapakis, G; Mavromoustakos, T; Matsoukas, J Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur J Med Chem62:352-70 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
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| Type: | Protein |
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| Mol. Mass.: | 41080.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30556 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| BDBM82258 |
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| n/a |
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| Name | BDBM82258 |
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| Synonyms: | CAS_114798-26-4 | Losartan | NSC_3961 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23ClN6O |
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| Mol. Mass. | 422.911 |
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| SMILES | CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 |
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| Structure | 
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