| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Ligand | BDBM50491040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_957666 (CHEMBL2378594) |
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| IC50 | 22±n/a nM |
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| Citation |  Hale, MR; Hill, P; Lahiri, S; Miller, MD; Ross, P; Alm, R; Gao, N; Kutschke, A; Johnstone, M; Prince, B; Thresher, J; Yang, W Exploring the UDP pocket of LpxC through amino acid analogs. Bioorg Med Chem Lett23:2362-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
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| Type: | Enzyme |
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| Mol. Mass.: | 33952.00 |
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| Organism: | Escherichia coli |
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| Description: | P0A725 |
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| Residue: | 305 |
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| Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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| BDBM50491040 |
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| n/a |
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| Name | BDBM50491040 |
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| Synonyms: | CHEMBL2377689 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O3S |
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| Mol. Mass. | 380.46 |
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| SMILES | ONC(=O)C1(CCSCC1)NC(=O)c1ccc(cc1)C#Cc1ccccc1 |
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| Structure | 
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