| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50491818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_963147 (CHEMBL2390789) |
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| IC50 | 1726±n/a nM |
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| Citation |  Guerrant, W; Patil, V; Canzoneri, JC; Yao, LP; Hood, R; Oyelere, AK Dual-acting histone deacetylase-topoisomerase I inhibitors. Bioorg Med Chem Lett23:3283-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50491818 |
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| n/a |
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| Name | BDBM50491818 |
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| Synonyms: | CHEMBL2386905 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N6O7 |
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| Mol. Mass. | 574.5845 |
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| SMILES | CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCc3cn(CCCC(=O)NO)nn3)cc12 |r| |
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| Structure | 
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