Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50037123 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_157870 (CHEMBL879227) |
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Ki | 270±n/a nM |
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Citation | Thompson, SK; Murthy, KH; Zhao, B; Winborne, E; Green, DW; Fisher, SM; DesJarlais, RL; Tomaszek, TA; Meek, TD; Gleason, JG Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere. J Med Chem37:3100-7 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50037123 |
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n/a |
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Name | BDBM50037123 |
Synonyms: | CHEMBL108226 | {(1S,2S,4R)-1-Benzyl-4-[5-(2,2-dimethyl-but-3-enoyl)-1H-imidazol-2-yl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester |
Type | Small organic molecule |
Emp. Form. | C32H41N3O4 |
Mol. Mass. | 531.6856 |
SMILES | CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](Cc1ccccc1)c1ncc([nH]1)C(=O)C(C)(C)C=C |
Structure |
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