| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50037291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_201955 (CHEMBL809142) |
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| IC50 | 14±n/a nM |
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| Citation |  Procopiou, PA; Bailey, EJ; Bamford, MJ; Craven, AP; Dymock, BW; Houston, JG; Hutson, JL; Kirk, BE; McCarthy, AD; Sareen, M The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues. J Med Chem37:3274-81 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48114.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1352847 |
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| Residue: | 417 |
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| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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| BDBM50037291 |
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| n/a |
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| Name | BDBM50037291 |
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| Synonyms: | (1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octanoyloxy)-1-((R)-3,5-dimethyl-6-phenyl-hexyl)-4,7-dihydroxy-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid | CHEMBL111439 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H48O12 |
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| Mol. Mass. | 636.727 |
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| SMILES | CC[C@H](C)C[C@H](C)CCC(=O)O[C@@H]1[C@@H](O)[C@]2(CCC(C)C[C@@H](C)Cc3ccccc3)O[C@@]1(C(O)=O)[C@@](O)([C@H](O2)C(O)=O)C(O)=O |
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| Structure | 
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