Reaction Details |
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Target | Sterol O-acyltransferase 1 |
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Ligand | BDBM50037661 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_28496 (CHEMBL645926) |
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IC50 | 30±n/a nM |
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Citation | Higley, CA; Wilde, RG; Maduskuie, TP; Johnson, AL; Pennev, P; Billheimer, JT; Robinson, CS; Gillies, PJ; Wexler, RR Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles. J Med Chem37:3511-22 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sterol O-acyltransferase 1 |
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Name: | Sterol O-acyltransferase 1 |
Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
Type: | PROTEIN |
Mol. Mass.: | 64165.56 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_28796 |
Residue: | 545 |
Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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BDBM50037661 |
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n/a |
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Name | BDBM50037661 |
Synonyms: | 2-Cyclohexyl-N-[5-(4,5-diphenyl-1H-imidazol-2-ylsulfanyl)-pentyl]-N-heptyl-acetamide | CHEMBL119645 |
Type | Small organic molecule |
Emp. Form. | C35H49N3OS |
Mol. Mass. | 559.848 |
SMILES | CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)C(=O)CC1CCCCC1 |
Structure |
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