| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50492589 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_974280 (CHEMBL2411710) |
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| IC50 | 217±n/a nM |
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| Citation |  Wang, ZC; Qin, YJ; Wang, PF; Yang, YA; Wen, Q; Zhang, X; Qiu, HY; Duan, YT; Wang, YT; Sang, YL; Zhu, HL Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis. Eur J Med Chem66:1-11 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50492589 |
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| n/a |
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| Name | BDBM50492589 |
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| Synonyms: | CHEMBL2408090 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16ClN3O5S |
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| Mol. Mass. | 457.887 |
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| SMILES | Cc1cc(NS(=O)(=O)c2ccc(cc2)\N=C\c2c(Cl)c3cc(C)ccc3oc2=O)no1 |
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| Structure | 
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