| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
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| Ligand | BDBM50392788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_974314 (CHEMBL2411893) |
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| IC50 | 39±n/a nM |
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| Citation |  Patel, PR; Sun, H; Li, SQ; Shen, M; Khan, J; Thomas, CJ; Davis, MI Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorg Med Chem Lett23:4398-403 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Yes |
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| Name: | Tyrosine-protein kinase Yes |
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| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
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| Type: | Protein |
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| Mol. Mass.: | 60801.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07947 |
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| Residue: | 543 |
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| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
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| BDBM50392788 |
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| n/a |
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| Name | BDBM50392788 |
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| Synonyms: | CHEMBL457614 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19ClFN7O |
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| Mol. Mass. | 391.83 |
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| SMILES | CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)[nH]n1 |r| |
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| Structure | 
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