| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50038273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54267 (CHEMBL669263) |
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| pH | 6.6±n/a |
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| Kd | 2900±n/a nM |
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| Comments | extracted |
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| Citation |  Ivery, MT; Gready, JE Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase. J Med Chem37:4211-21 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
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| BDBM50038273 |
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| n/a |
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| Name | BDBM50038273 |
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| Synonyms: | 2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one | CHEMBL341200 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H12N4O |
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| Mol. Mass. | 192.2178 |
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| SMILES | CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| |
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| Structure | 
|
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