BDBM50038273 2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]pyrimidin-4-one::CHEMBL341200

SMILES: CN1C(C)=CC=C2C(=O)NC(N)N=C12

InChI Key: InChIKey=QORTUZFRDCQSSV-UHFFFAOYSA-N

Data: 4 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038273   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038273 (2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-6-7(13(5)2)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038273 (2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-6-7(13(5)2)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.10E+4	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038273 (2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-6-7(13(5)2)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for human dihydrofolate reductase in the presence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50038273 (2-Amino-7,8-dimethyl-2,8-dihydro-3H-pyrido[2,3-d]p...) Show SMILES CN1C(C)=CC=C2C(=O)NC(N)N=C12 |c:3,t:5,12| Show InChI InChI=1S/C9H12N4O/c1-5-3-4-6-7(13(5)2)11-9(10)12-8(6)14/h3-4,9H,10H2,1-2H3,(H,12,14)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	1.10E+4	n/a	n/a	n/a	6.6	n/a
University of Sydney Curated by ChEMBL					Assay Description Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH				J Med Chem 37: 4211-21 (1995) BindingDB Entry DOI: 10.7270/Q2WW7GQH
					More data for this Ligand-Target Pair