| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
|---|
| Ligand | BDBM50040826 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_28192 (CHEMBL637685) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Kumazawa, T; Yanase, M; Harakawa, H; Obase, H; Shirakura, S; Ohishi, E; Oda, S; Kubo, K; Yamada, K Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides. J Med Chem37:804-10 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA:cholesterol acyltransferase |
|---|
| Name: | Acyl-CoA:cholesterol acyltransferase |
|---|
| Synonyms: | ACAT |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 35405.31 |
|---|
| Organism: | Oryctolagus cuniculus |
|---|
| Description: | n/a |
|---|
| Residue: | 305 |
|---|
| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
|---|
| BDBM50040826 |
|---|
| n/a |
|---|
| Name | BDBM50040826 |
|---|
| Synonyms: | 10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxylic acid (2,6-diisopropyl-phenyl)-amide | CHEMBL353609 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H31NO |
|---|
| Mol. Mass. | 397.5518 |
|---|
| SMILES | CC(C)c1cccc(C(C)C)c1NC(=O)C1c2ccccc2CCc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
