| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin beta-2B chain |
|---|
| Ligand | BDBM50041121 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_211333 (CHEMBL820776) |
|---|
| IC50 | 840.0±n/a nM |
|---|
| Citation |  Li, L; Wang, HK; Kuo, SC; Wu, TS; Lednicer, D; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem37:1126-35 (1994) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin beta-2B chain |
|---|
| Name: | Tubulin beta-2B chain |
|---|
| Synonyms: | TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49932.38 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_211651 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
|
|
|
|---|
| BDBM50041121 |
|---|
| n/a |
|---|
| Name | BDBM50041121 |
|---|
| Synonyms: | 2-(3-Dimethylamino-phenyl)-6-methoxy-1H-quinolin-4-one | CHEMBL14290 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18N2O2 |
|---|
| Mol. Mass. | 294.3477 |
|---|
| SMILES | COc1ccc2nc(cc(O)c2c1)-c1cccc(c1)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
