| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
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| Ligand | BDBM50041290 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28504 (CHEMBL645933) |
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| IC50 | 135±n/a nM |
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| Citation |  McCarthy, PA; Hamanaka, ES; Marzetta, CA; Bamberger, MJ; Gaynor, BJ; Chang, G; Kelly, SE; Inskeep, PB; Mayne, JT; Beyer, TA Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT). J Med Chem37:1252-5 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol O-acyltransferase 1 |
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| Name: | Sterol O-acyltransferase 1 |
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| Synonyms: | ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64165.56 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_28796 |
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| Residue: | 545 |
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| Sequence: | MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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| BDBM50041290 |
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| n/a |
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| Name | BDBM50041290 |
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| Synonyms: | (S)-2-Hexylsulfanyl-decanoic acid (6-methylsulfanyl-quinolin-5-yl)-amide | CHEMBL25276 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H40N2OS2 |
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| Mol. Mass. | 460.739 |
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| SMILES | CCCCCCCC[C@H](SCCCCCC)C(=O)Nc1c(SC)ccc2ncccc12 |
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| Structure | 
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