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TargetNeutrophil elastase
LigandBDBM50037348
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63996 (CHEMBL673105)
Ki 1.8±n/a nM
Citation Brown, FJ; Andisik, DW; Bernstein, PR; Bryant, CB; Ceccarelli, C; Damewood, JR; Edwards, PD; Earley, RA; Feeney, S; Green, RC Design of orally active, non-peptidic inhibitors of human leukocyte elastase. J Med Chem37:1259-61 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50037348
n/a
NameBDBM50037348
Synonyms:1N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)-2-(3-amino-sulfonylaminobenzyl-2-oxo-6-phenyl-1,2-dihydro-1-pyridinyl)acetamide(0.25M H2O) | 2-{3-[Benzylamino-sulfanylamino]-2-oxo-6-phenyl-2H-pyridin-1-yl}-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide | CHEMBL282694
TypeSmall organic molecule
Emp. Form.C26H27F3N4O5S
Mol. Mass.564.577
SMILESCC(C)C(NC(=O)Cn1c(ccc(NS(=O)(=O)NCc2ccccc2)c1=O)-c1ccccc1)C(=O)C(F)(F)F
Structure
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