Reaction Details |
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Target | Mitogen-activated protein kinase 10 |
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Ligand | BDBM50495040 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1281650 (CHEMBL3102587) |
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IC50 | 32±n/a nM |
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Citation | He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett24:161-4 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 10 |
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Name: | Mitogen-activated protein kinase 10 |
Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
Type: | Enzyme |
Mol. Mass.: | 52586.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 464 |
Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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BDBM50495040 |
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n/a |
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Name | BDBM50495040 |
Synonyms: | CHEMBL3099968 |
Type | Small organic molecule |
Emp. Form. | C25H23FN4O2 |
Mol. Mass. | 430.4741 |
SMILES | Cc1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 |
Structure |
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