| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha inhibitor |
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| Ligand | BDBM50495472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1287193 (CHEMBL3112250) |
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| IC50 | 25000±n/a nM |
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| Citation |  Rotili, D; Tomassi, S; Conte, M; Benedetti, R; Tortorici, M; Ciossani, G; Valente, S; Marrocco, B; Labella, D; Novellino, E; Mattevi, A; Altucci, L; Tumber, A; Yapp, C; King, ON; Hopkinson, RJ; Kawamura, A; Schofield, CJ; Mai, A Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem57:42-55 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha inhibitor |
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| Name: | Hypoxia-inducible factor 1-alpha inhibitor |
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| Synonyms: | FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40278.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWT6 |
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| Residue: | 349 |
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| Sequence: | MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE
PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR
EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG
QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS
QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA
PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
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| BDBM50495472 |
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| n/a |
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| Name | BDBM50495472 |
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| Synonyms: | CHEMBL3108952 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClN3O2 |
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| Mol. Mass. | 355.818 |
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| SMILES | Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccc(O)c3ncccc23)cc1 |r| |
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| Structure | 
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