Reaction Details |
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Target | Lysine-specific demethylase 4E |
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Ligand | BDBM26119 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1287196 (CHEMBL3112253) |
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IC50 | 5000±n/a nM |
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Citation | Rotili, D; Tomassi, S; Conte, M; Benedetti, R; Tortorici, M; Ciossani, G; Valente, S; Marrocco, B; Labella, D; Novellino, E; Mattevi, A; Altucci, L; Tumber, A; Yapp, C; King, ON; Hopkinson, RJ; Kawamura, A; Schofield, CJ; Mai, A Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem57:42-55 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific demethylase 4E |
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Name: | Lysine-specific demethylase 4E |
Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
Type: | Enzyme |
Mol. Mass.: | 56815.71 |
Organism: | Homo sapiens (Human) |
Description: | B2RXH2 |
Residue: | 506 |
Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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BDBM26119 |
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n/a |
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Name | BDBM26119 |
Synonyms: | 2-[4-(methoxycarbonyl)pyridin-2-yl]pyridine-4-carboxylic acid | bipyridine analogue, 7 |
Type | Small organic molecule |
Emp. Form. | C13H10N2O4 |
Mol. Mass. | 258.2295 |
SMILES | COC(=O)c1ccnc(c1)-c1cc(ccn1)C(O)=O |
Structure |
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