| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4E |
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| Ligand | BDBM50495472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1287196 (CHEMBL3112253) |
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| IC50 | 3900±n/a nM |
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| Citation |  Rotili, D; Tomassi, S; Conte, M; Benedetti, R; Tortorici, M; Ciossani, G; Valente, S; Marrocco, B; Labella, D; Novellino, E; Mattevi, A; Altucci, L; Tumber, A; Yapp, C; King, ON; Hopkinson, RJ; Kawamura, A; Schofield, CJ; Mai, A Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem57:42-55 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4E |
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| Name: | Lysine-specific demethylase 4E |
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| Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56815.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2RXH2 |
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| Residue: | 506 |
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| Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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| BDBM50495472 |
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| n/a |
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| Name | BDBM50495472 |
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| Synonyms: | CHEMBL3108952 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClN3O2 |
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| Mol. Mass. | 355.818 |
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| SMILES | Cl.N[C@@H]1C[C@H]1c1ccc(NC(=O)c2ccc(O)c3ncccc23)cc1 |r| |
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| Structure | 
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