| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane prolyl 4-hydroxylase |
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| Ligand | BDBM50042876 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_223465 |
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| IC50 | 185±n/a nM |
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| Citation |  Hales, NJ; Beattie, JF Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives. J Med Chem36:3853-8 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane prolyl 4-hydroxylase |
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| Name: | Transmembrane prolyl 4-hydroxylase |
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| Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56654.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXG6 |
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| Residue: | 502 |
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| Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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| BDBM50042876 |
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| n/a |
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| Name | BDBM50042876 |
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| Synonyms: | CHEMBL332005 | [2,2']Bipyridinyl-5,5'-dicarboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C12H8N2O4 |
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| Mol. Mass. | 244.2029 |
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| SMILES | OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O |
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| Structure | 
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