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TargetTransmembrane prolyl 4-hydroxylase
LigandBDBM50042874
Substrate/Competitorn/a
Meas. Tech.ChEBML_223465
IC50 34200±n/a nM
Citation Hales, NJ; Beattie, JF Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives. J Med Chem36:3853-8 (1994) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Transmembrane prolyl 4-hydroxylase
Name:Transmembrane prolyl 4-hydroxylase
Synonyms:Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase
Type:Enzyme
Mol. Mass.:56654.25
Organism:Homo sapiens (Human)
Description:Q9NXG6
Residue:502
Sequence:
MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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  Blast E-value cutoff:
BDBM50042874
n/a
NameBDBM50042874
Synonyms:2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl | 2,2'-dipyridine | 2,2'-dipyridyl | 2-(2-pyridyl)pyridine | CHEMBL39879 | US10196346, Bipyridine | alpha,alpha'-bipyridine | alpha,alpha'-bipyridyl | alpha,alpha'-dipyridine | alpha,alpha'-dipyridyl | bpy
TypeSmall organic molecule
Emp. Form.C10H8N2
Mol. Mass.156.1839
SMILESc1ccc(nc1)-c1ccccn1
Structure
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