Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50043963 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_201739 (CHEMBL803935) |
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IC50 | 60±n/a nM |
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Citation | Reddy, NL; Hu, LY; Cotter, RE; Fischer, JB; Wong, WJ; McBurney, RN; Weber, E; Holmes, DL; Wong, ST; Prasad, R Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J Med Chem37:260-7 (1994) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50043963 |
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n/a |
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Name | BDBM50043963 |
Synonyms: | CHEMBL88660 | N-(3-Ethyl-phenyl)-4-phenyl-piperidine-1-carboxamidine |
Type | Small organic molecule |
Emp. Form. | C20H25N3 |
Mol. Mass. | 307.4326 |
SMILES | CCc1cccc(c1)N=C(N)N1CCC(CC1)c1ccccc1 |w:8.8| |
Structure |
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