| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
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| Ligand | BDBM50496606 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1300504 (CHEMBL3135820) |
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| IC50 | >250000±n/a nM |
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| Citation |  Lin, H; Annamalai, T; Bansod, P; Tse-Dinh, YC; Sun, D Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors. Medchemcomm4:0 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 1 |
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| Name: | DNA topoisomerase 1 |
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| Synonyms: | DNA topoisomerase I | supX |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97991.27 |
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| Organism: | Yersinia pestis |
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| Description: | ChEMBL_104164 |
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| Residue: | 871 |
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| Sequence: | MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSANSAEEKAKKDDK
PKKKVKKDEKVALVNRMGVDPYHGWKAQYEILSGKEKVVAELKALAENADHIYLATDLDR
EGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNISRVNAQQARRFMDRV
VGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLVAKGDIPI
QMEVTHAHGKPFKPVNREQTHAALTLLENARYKVLDREDKPTSSKPSAPFITSTLQQAAS
TRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPATPNQ
YSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQRLYQLIWRQFVACQMPPAKYDSTTLT
VQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSDLDLQKLIPSQHFTKPP
ARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENF
RELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVM
TSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPDAEILNILEGDDAETN
ALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYEGPIVECEKC
GSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLLELPCEKSDAYFVLRD
GAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVVDKEGNKTLVRFSRK
TKQQYVSSEKDGKATGWSAFYIDGKWVEAKK
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| BDBM50496606 |
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| n/a |
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| Name | BDBM50496606 |
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| Synonyms: | CHEMBL3134409 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20 |
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| Mol. Mass. | 236.3514 |
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| SMILES | Cc1ccc(C)c(\C=C\c2cc(C)ccc2C)c1 |
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| Structure | 
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