Reaction Details |
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Target | Gamma-aminobutyric acid receptor subunit alpha-2 |
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Ligand | BDBM50044427 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_68738 |
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Ki | 6950±n/a nM |
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Citation | Linders, JT; Monn, JA; Mattson, MV; George, C; Jacobson, AE; Rice, KC Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site. J Med Chem36:2499-507 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gamma-aminobutyric acid receptor subunit alpha-2 |
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Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
Synonyms: | GABA A Alpha2Beta2Gamma2 | GABA A alpha2 | GABA A receptor alpha-2/beta-2/gamma-2 | GABA receptor alpha-2 subunit | GABA(A) receptor subunit alpha-2 | GBRA2_RAT | Gabra-2 | Gabra2 | Gamma-aminobutyric acid receptor subunit alpha-2 |
Type: | Enzyme |
Mol. Mass.: | 51195.57 |
Organism: | Rattus norvegicus (Rat) |
Description: | P23576 |
Residue: | 451 |
Sequence: | MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
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BDBM50044427 |
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n/a |
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Name | BDBM50044427 |
Synonyms: | 1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10,12,14-hexaen-4-yl isothiocyanate | CHEMBL312471 |
Type | Small organic molecule |
Emp. Form. | C17H14N2S |
Mol. Mass. | 278.371 |
SMILES | C[C@]12N[C@H](Cc3ccc(cc13)N=C=S)c1ccccc21 |
Structure |
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