Reaction Details | |||
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Target | Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 | ||
Ligand | BDBM50000663 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_138216 | ||
Ki | >100000±n/a nM | ||
Citation | Linders, JT; Monn, JA; Mattson, MV; George, C; Jacobson, AE; Rice, KC Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site. J Med Chem36:2499-507 (1993) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 | |||
Name: | Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 | ||
Synonyms: | Muscarinic acetylcholine receptor | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of ChEMBL is 1821274 | ||
Components: | This complex has 5 components. | ||
Component 1 | |||
Name: | Muscarinic acetylcholine receptor M1 | ||
Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 51390.46 | ||
Organism: | RAT | ||
Description: | P08482 | ||
Residue: | 460 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Muscarinic acetylcholine receptor M3 | ||
Synonyms: | ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 66086.66 | ||
Organism: | RAT | ||
Description: | Cholinergic, muscarinic M3 CHRM3 RAT::P08483 | ||
Residue: | 589 | ||
Sequence: |
| ||
Component 3 | |||
Name: | Muscarinic acetylcholine receptor M4 | ||
Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 52841.70 | ||
Organism: | RAT | ||
Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 | ||
Residue: | 477 | ||
Sequence: |
| ||
Component 4 | |||
Name: | Muscarinic acetylcholine receptor M5 | ||
Synonyms: | ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 60161.80 | ||
Organism: | RAT | ||
Description: | Cholinergic, muscarinic M5 CHRM5 RAT::P08911 | ||
Residue: | 531 | ||
Sequence: |
| ||
Component 5 | |||
Name: | Muscarinic acetylcholine receptor M2 | ||
Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 51555.53 | ||
Organism: | RAT | ||
Description: | P10980 | ||
Residue: | 466 | ||
Sequence: |
| ||
BDBM50000663 | |||
n/a | |||
Name | BDBM50000663 | ||
Synonyms: | (+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | (+)-MK-801 | (+)MK-801 | (+/-) MK-8011-methyl-(9R,1R)-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | (+/-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | (+/-)-MK801 | (-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | (-)-MK801 | (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2(7),3,5,10(15),11,13-hexaene | (1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2,4,6,10(15),11,13-hexaene | (5S,10R)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine | (5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine | (Dizocilpine)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | (MK-801)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | 1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene | 1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene(MK-801) | 1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10,12,14-hexaene | 1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10(15),11,13-hexaene | 10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine.(MK-801) | CHEMBL284237 | MK-801 | MK-801 (Dizocilpine) | MK-801,(+) | MK-801,(-) | dizocilpine | ||
Type | Small organic molecule | ||
Emp. Form. | C16H15N | ||
Mol. Mass. | 221.297 | ||
SMILES | C[C@]12NC(Cc3ccccc13)c1ccccc21 | ||
Structure |