Reaction Details |
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Target | Cytochrome b-245 heavy chain |
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Ligand | BDBM50497260 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1390858 (CHEMBL3391326) |
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IC50 | >100000±n/a nM |
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Citation | Cifuentes-Pagano, E; Saha, J; Csányi, G; Ghouleh, IA; Sahoo, S; Rodríguez, A; Wipf, P; Pagano, PJ; Skoda, EM Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm4:1085-1092 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome b-245 heavy chain |
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Name: | Cytochrome b-245 heavy chain |
Synonyms: | CGD91-phox | CY24B_HUMAN | CYBB | Cytochrome b(558) subunit beta | Cytochrome b-245, beta polypeptide [Homo sapiens] | Cytochrome b558 subunit beta | Heme-binding membrane glycoprotein gp91phox | NADPH oxidase 2 | NADPH oxidase 2 (NOX2) | NOX2 | Neutrophil cytochrome b 91 kDa polypeptide | Superoxide-generating NADPH oxidase heavy chain subunit | gp91-1 | gp91-phox | p22 phagocyte B-cytochrome |
Type: | Enzyme |
Mol. Mass.: | 65355.82 |
Organism: | Homo sapiens (Human) |
Description: | P04839 |
Residue: | 570 |
Sequence: | MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHL
FNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGV
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHN
ITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASIL
KSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYL
TGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPE
ALAETLSKQSISNSESGPRGVHFIFNKENF
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BDBM50497260 |
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n/a |
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Name | BDBM50497260 |
Synonyms: | CHEMBL3347567 |
Type | Small organic molecule |
Emp. Form. | C28H35Cl2N |
Mol. Mass. | 456.49 |
SMILES | [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1CCCCC)c1c(cccc21)-c1ccc(Cl)c(Cl)c1 |r,TLB:20:19:3.2:13.8,9:8:3.2:24.19,THB:14:13:3.2:24.19| |
Structure |
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