| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 4 |
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| Ligand | BDBM50497265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1390861 (CHEMBL3391329) |
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| IC50 | >100000±n/a nM |
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| Citation |  Cifuentes-Pagano, E; Saha, J; Csányi, G; Ghouleh, IA; Sahoo, S; Rodríguez, A; Wipf, P; Pagano, PJ; Skoda, EM Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm4:1085-1092 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 4 |
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| Name: | NADPH oxidase 4 |
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| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66954.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792879 |
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| Residue: | 578 |
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| Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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| BDBM50497265 |
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| n/a |
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| Name | BDBM50497265 |
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| Synonyms: | CHEMBL3347503 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28FN |
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| Mol. Mass. | 349.4842 |
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| SMILES | [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1Cc1cccc(F)c1)c1ccccc21 |r,TLB:23:22:3.2:13.8,9:8:3.2:27.22,THB:14:13:3.2:27.22| |
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| Structure | 
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