Reaction Details |
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Target | Retinoic acid receptor gamma |
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Ligand | BDBM50045278 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_163495 |
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EC50 | 550±n/a nM |
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Citation | Jong, L; Lehmann, JM; Hobbs, PD; Harlev, E; Huffman, JC; Pfahl, M; Dawson, MI Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity. J Med Chem36:2605-13 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor gamma |
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Name: | Retinoic acid receptor gamma |
Synonyms: | NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50345.43 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1458016 |
Residue: | 454 |
Sequence: | MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS
LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK
NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY
ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK
IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH
NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA
LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE
MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
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BDBM50045278 |
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n/a |
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Name | BDBM50045278 |
Synonyms: | 4-[(E)-2-(1,2,3,4-Tetrahydro-1,4-methano-naphthalen-6-yl)-propenyl]-benzoic acid | 4-[2-(1,2,3,4-Tetrahydro-1,4-methano-naphthalen-6-yl)-propenyl]-benzoic acid | CHEMBL40007 |
Type | Small organic molecule |
Emp. Form. | C21H20O2 |
Mol. Mass. | 304.3823 |
SMILES | C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2C3CCC(C3)c2c1 |
Structure |
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