Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50045811

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_49880

986.0±n/a nM

Citation

Blommaert, AG; Weng, JH; Dorville, A; McCort, I; Ducos, B; Durieux, C; Roques, BP Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties. J Med Chem36:2868-77 (1993) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

48445.79

Organism:

Homo sapiens (Human)

Description:

Stable expression of human CCK-2 receptors in HEK 293 cells.

Residue:

447

Sequence:

MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50045811

n/a

Name

BDBM50045811

Synonyms:

CHEMBL96036 | [2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-acetic acid

Type

Small organic molecule

Emp. Form.

C25H31N3O5

Mol. Mass.

453.5307

SMILES

CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(O)=O |wU:21.28,19.20,23.24,wD:17.19,TLB:15:16:22:19.24.20,THB:18:17:22:19.24.20,18:19:22:16.17.25,(14.82,-10.14,;13.5,-10.93,;12.18,-11.69,;12.19,-13.24,;13.1,-14.47,;12.19,-15.73,;10.72,-15.27,;9.39,-16.04,;8.06,-15.27,;8.06,-13.72,;9.39,-12.95,;10.72,-13.72,;12.01,-10.51,;10.68,-9.75,;9.58,-10.83,;10.28,-8.25,;8.79,-7.86,;7.46,-7.07,;6.9,-5.66,;5.27,-5.81,;4.15,-6.86,;4.71,-8.25,;5.99,-8.91,;7.06,-7.87,;6.48,-6.58,;6.32,-8.16,;14.84,-11.68,;14.82,-13.22,;16.38,-11.68,;17.15,-13.01,;18.67,-13.01,;19.45,-14.33,;19.76,-11.91,)|

Structure