Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50045815

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_49880

134±n/a nM

Citation

Blommaert, AG; Weng, JH; Dorville, A; McCort, I; Ducos, B; Durieux, C; Roques, BP Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties. J Med Chem36:2868-77 (1993) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

48445.79

Organism:

Homo sapiens (Human)

Description:

Stable expression of human CCK-2 receptors in HEK 293 cells.

Residue:

447

Sequence:

MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50045815

n/a

Name

BDBM50045815

Synonyms:

CHEMBL98516 | {[2-(Adamantan-2-yloxycarbonylamino)-2-methyl-3-naphthalen-1-yl-propionyl]-phenethyl-amino}-acetic acid

Type

Small organic molecule

Emp. Form.

C35H40N2O5

Mol. Mass.

568.7025

SMILES

CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(O)=O |wU:22.24,20.28,18.20,wD:24.27,TLB:16:17:19:22.26.21,THB:23:24:19:22.26.21,23:22:19:17.24.25,(13.85,-9.4,;12.53,-10.18,;11.2,-10.95,;11.21,-12.51,;12.54,-13.27,;12.56,-14.8,;11.22,-15.58,;9.87,-14.82,;8.57,-15.6,;7.23,-14.85,;7.21,-13.3,;8.54,-12.53,;9.87,-13.29,;11.02,-9.78,;9.69,-9.01,;8.59,-10.09,;9.29,-7.51,;7.79,-7.12,;6.06,-7.12,;4.98,-8.16,;3.7,-7.51,;3.14,-6.1,;4.26,-5.05,;5.9,-4.89,;6.46,-6.31,;5.32,-7.42,;5.48,-5.82,;13.87,-10.95,;13.85,-12.49,;15.41,-10.94,;16.18,-9.61,;17.72,-9.61,;18.49,-8.26,;17.71,-6.94,;18.48,-5.61,;20.02,-5.6,;20.81,-6.94,;20.02,-8.28,;16.19,-12.28,;17.73,-12.28,;18.5,-13.62,;18.49,-10.94,)|

Structure