Reaction Details | |||
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Target | Gastrin/cholecystokinin type B receptor | ||
Ligand | BDBM50045808 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_49880 | ||
Ki | 51±n/a nM | ||
Citation | Blommaert, AG; Weng, JH; Dorville, A; McCort, I; Ducos, B; Durieux, C; Roques, BP Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties. J Med Chem36:2868-77 (1993) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gastrin/cholecystokinin type B receptor | |||
Name: | Gastrin/cholecystokinin type B receptor | ||
Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 48445.79 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. | ||
Residue: | 447 | ||
Sequence: |
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BDBM50045808 | |||
n/a | |||
Name | BDBM50045808 | ||
Synonyms: | CHEMBL432389 | [1-[2-(4-Bromo-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester | ||
Type | Small organic molecule | ||
Emp. Form. | C31H36BrN3O3 | ||
Mol. Mass. | 578.54 | ||
SMILES | CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 |wU:21.23,19.27,17.19,wD:23.26,TLB:15:16:18:21.25.20,THB:22:23:18:21.25.20,22:21:16.23.24:18,(13,-12.04,;11.67,-12.82,;10.34,-13.59,;10.34,-15.14,;11.25,-16.38,;10.36,-17.64,;8.89,-17.17,;7.54,-17.94,;6.21,-17.17,;6.21,-15.62,;7.54,-14.85,;8.87,-15.62,;10.17,-12.42,;8.83,-11.65,;7.73,-12.72,;8.43,-10.16,;6.95,-9.76,;5.2,-9.76,;4.14,-10.8,;2.85,-10.16,;2.31,-8.75,;3.41,-7.7,;5.05,-7.54,;5.62,-8.96,;4.46,-10.06,;4.64,-8.47,;13,-13.59,;13,-15.12,;14.54,-13.58,;15.31,-12.25,;16.85,-12.25,;17.62,-10.9,;16.83,-9.59,;17.6,-8.26,;19.14,-8.24,;19.91,-6.91,;19.93,-9.59,;19.16,-10.92,)| | ||
Structure |