| Reaction Details |
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 | Report a problem with these data |
| Target | Friend leukemia integration 1 transcription factor |
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| Ligand | BDBM50497659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1440214 (CHEMBL3383759) |
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| IC50 | 330±n/a nM |
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| Citation |  Tosso, PN; Kong, Y; Scher, L; Cummins, R; Schneider, J; Rahim, S; Holman, KT; Toretsky, J; Wang, K; Üren, A; Brown, ML Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma. J Med Chem57:10290-303 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Friend leukemia integration 1 transcription factor |
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| Name: | Friend leukemia integration 1 transcription factor |
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| Synonyms: | FLI1 | FLI1_HUMAN | Friend leukemia integration 1 transcription factor | Proto-oncogene Fli-1 | Transcription factor ERGB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50985.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_117112 |
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| Residue: | 452 |
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| Sequence: | MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQPHKINPLPPQQEWINQ
PVRVNVKREYDHMNGSRESPVDCSVSKCSKLVGGGESNPMNYNSYMDEKNGPPPPNMTTN
ERRVIVPADPTLWTQEHVRQWLEWAIKEYSLMEIDTSFFQNMDGKELCKMNKEDFLRATT
LYNTEVLLSHLSYLRESSLLAYNTTSHTDQSSRLSVKEDPSYDSVRRGAWGNNMNSGLNK
SPPLGGAQTISKNTEQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANASCI
TWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF
DFHGIAQALQPHPTESSMYKYPSDISYMPSYHAHQQKVNFVPPHPSSMPVTSSSFFGAAS
QYWTSPTGGIYPNPNVPRHPNTHVPSHLGSYY
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| BDBM50497659 |
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| n/a |
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| Name | BDBM50497659 |
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| Synonyms: | CHEMBL3360406 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13Cl2NO3S |
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| Mol. Mass. | 382.261 |
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| SMILES | CSc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl |
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| Structure | 
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