| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Ligand | BDBM50502339 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1807409 (CHEMBL4306768) |
|---|
| IC50 | 0.400000±n/a nM |
|---|
| Citation |  Harris, PA; Marinis, JM; Lich, JD; Berger, SB; Chirala, A; Cox, JA; Eidam, PM; Finger, JN; Gough, PJ; Jeong, JU; Kang, J; Kasparcova, V; Leister, LK; Mahajan, MK; Miller, G; Nagilla, R; Ouellette, MT; Reilly, MA; Rendina, AR; Rivera, EJ; Sun, HH; Thorpe, JH; Totoritis, RD; Wang, W; Wu, D; Zhang, D; Bertin, J; Marquis, RW Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett10:857-862 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 75926.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13546 |
|---|
| Residue: | 671 |
|---|
| Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
|
|
|
|---|
| BDBM50502339 |
|---|
| n/a |
|---|
| Name | BDBM50502339 |
|---|
| Synonyms: | CHEMBL4452233 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17F2N5O2 |
|---|
| Mol. Mass. | 397.3781 |
|---|
| SMILES | Fc1cc(F)c2NC(=O)[C@H](CCc2c1)NC(=O)c1n[nH]c(Cc2ccccc2)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
