| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50498741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1522234 (CHEMBL3626463) |
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| IC50 | 4660±n/a nM |
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| Citation |  Wan, ZY; Yao, J; Mao, TQ; Wang, XL; Wang, HF; Chen, WX; Yin, H; Chen, FE; De Clercq, E; Daelemans, D; Pannecouque, C Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue. Eur J Med Chem102:215-22 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50498741 |
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| n/a |
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| Name | BDBM50498741 |
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| Synonyms: | CHEMBL3623092 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N4O5S |
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| Mol. Mass. | 452.483 |
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| SMILES | COc1ccc(NC(=O)CS(=O)(=O)c2nccc(Oc3c(C)cc(cc3C)C#N)n2)cc1 |
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| Structure | 
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