| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50047873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_36941 (CHEMBL648844) |
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| IC50 | 60±n/a nM |
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| Citation |  Ashton, WT; Cantone, CL; Chang, LL; Hutchins, SM; Strelitz, RA; MacCoss, M; Chang, RS; Lotti, VJ; Faust, KA; Chen, TB Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. J Med Chem36:591-609 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41009.15 |
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| Organism: | RABBIT |
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| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
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| Residue: | 359 |
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| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
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| BDBM50047873 |
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| n/a |
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| Name | BDBM50047873 |
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| Synonyms: | CHEMBL154772 | N-{4-[3-Butyl-5-(2-cyano-benzylsulfanyl)-[1,2,4]triazol-4-ylmethyl]-phenyl}-phthalamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C29H27N5O3S |
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| Mol. Mass. | 525.621 |
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| SMILES | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1 |
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| Structure | 
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