| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50498909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1539709 (CHEMBL3736606) |
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| IC50 | 61±n/a nM |
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| Citation |  Han, XF; He, X; Wang, M; Xu, D; Hao, LP; Liang, AH; Zhang, J; Zhou, ZM Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral center. Eur J Med Chem103:473-87 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
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| Type: | Protein |
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| Mol. Mass.: | 41080.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30556 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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| BDBM50498909 |
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| n/a |
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| Name | BDBM50498909 |
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| Synonyms: | CHEMBL3735804 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H35N3O3S |
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| Mol. Mass. | 577.736 |
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| SMILES | CCCSc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(=O)NC[C@H](C)c1ccccc1 |r| |
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| Structure | 
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