Reaction Details |
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Target | Integrase |
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Ligand | BDBM50498968 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1538045 (CHEMBL3738751) |
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IC50 | 16300±n/a nM |
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Citation | Sari, O; Roy, V; Métifiot, M; Marchand, C; Pommier, Y; Bourg, S; Bonnet, P; Schinazi, RF; Agrofoglio, LA Synthesis of dihydropyrimidine ?,?-diketobutanoic acid derivatives targeting HIV integrase. Eur J Med Chem104:127-38 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50498968 |
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n/a |
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Name | BDBM50498968 |
Synonyms: | CHEMBL3736042 |
Type | Small organic molecule |
Emp. Form. | C32H28N2O7 |
Mol. Mass. | 552.5739 |
SMILES | CCOC(=O)c1c(nc(=O)n(Cc2ccc(cc2)C(=O)\C=C(/O)C(O)=O)c1-c1ccccc1)-c1cc(C)cc(C)c1 |
Structure |
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