| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50498953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1538045 (CHEMBL3738751) |
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| IC50 | 30700±n/a nM |
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| Citation |  Sari, O; Roy, V; Métifiot, M; Marchand, C; Pommier, Y; Bourg, S; Bonnet, P; Schinazi, RF; Agrofoglio, LA Synthesis of dihydropyrimidine ?,?-diketobutanoic acid derivatives targeting HIV integrase. Eur J Med Chem104:127-38 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50498953 |
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| n/a |
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| Name | BDBM50498953 |
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| Synonyms: | CHEMBL3735583 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26N2O7S |
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| Mol. Mass. | 522.57 |
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| SMILES | CCOC(=O)c1c(CC)nc(SCc2ccc(cc2)C(=O)\C=C(/O)C(O)=O)nc1-c1ccc(OC)cc1 |
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| Structure | 
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