| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
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| Ligand | BDBM50499277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1537949 (CHEMBL3738382) |
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| IC50 | 1.1±n/a nM |
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| Citation |  Nakano, H; Hasegawa, T; Saito, N; Furukawa, K; Mukaida, N; Kojima, H; Okabe, T; Nagano, T Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent. Bioorg Med Chem Lett25:5687-93 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-3 |
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| Name: | Serine/threonine-protein kinase pim-3 |
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| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
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| Type: | Protein |
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| Mol. Mass.: | 35888.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86V86 |
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| Residue: | 326 |
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| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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| BDBM50499277 |
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| n/a |
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| Name | BDBM50499277 |
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| Synonyms: | CHEMBL3735633 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N5O3 |
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| Mol. Mass. | 405.4497 |
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| SMILES | COc1ccc2C(=O)\C(Oc2c1CN1CCNC[C@@H]1C)=C\c1n[nH]c2ncccc12 |r| |
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| Structure | 
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