Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Ligand | BDBM50499415 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1539824 (CHEMBL3736962) |
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Ki | 740±n/a nM |
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Citation | Wan, Y; Wang, J; Sun, F; Chen, M; Hou, X; Fang, H Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors. Bioorg Med Chem23:7685-93 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
Type: | Membrane; Single-pass membrane protein |
Mol. Mass.: | 37332.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07820 |
Residue: | 350 |
Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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BDBM50499415 |
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n/a |
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Name | BDBM50499415 |
Synonyms: | CHEMBL3735919 |
Type | Small organic molecule |
Emp. Form. | C37H37BrClN3O7S |
Mol. Mass. | 783.128 |
SMILES | CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1)Oc1ccc(cc1)-c1ccccc1 |r| |
Structure |
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