| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 6 |
|---|
| Ligand | BDBM50499621 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1542401 (CHEMBL3743438) |
|---|
| IC50 | 6100±n/a nM |
|---|
| Citation |  Mandal, PK; Morlacchi, P; Knight, JM; Link, TM; Lee, GR; Nurieva, R; Singh, D; Dhanik, A; Kavraki, L; Corry, DB; Ladbury, JE; McMurray, JS Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem58:8970-84 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 6 |
|---|
| Name: | Signal transducer and activator of transcription 6 |
|---|
| Synonyms: | STAT6 | STAT6_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 94129.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_881634 |
|---|
| Residue: | 847 |
|---|
| Sequence: | MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
LRANPSW
|
|
|
|---|
| BDBM50499621 |
|---|
| n/a |
|---|
| Name | BDBM50499621 |
|---|
| Synonyms: | CHEMBL3741480 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H43N6O9P |
|---|
| Mol. Mass. | 674.6817 |
|---|
| SMILES | CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
