Reaction Details |
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Target | Sphingosine 1-phosphate receptor 5 |
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Ligand | BDBM50499636 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1542579 (CHEMBL3744618) |
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IC50 | 5.0±n/a nM |
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Citation | Hobson, AD; Harris, CM; van der Kam, EL; Turner, SC; Abibi, A; Aguirre, AL; Bousquet, P; Kebede, T; Konopacki, DB; Gintant, G; Kim, Y; Larson, K; Maull, JW; Moore, NS; Shi, D; Shrestha, A; Tang, X; Zhang, P; Sarris, KK Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. J Med Chem58:9154-70 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 5 |
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Name: | Sphingosine 1-phosphate receptor 5 |
Synonyms: | EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41796.42 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 398 |
Sequence: | MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
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BDBM50499636 |
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n/a |
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Name | BDBM50499636 |
Synonyms: | CHEMBL3741022 |
Type | Small organic molecule |
Emp. Form. | C18H16Cl2N2O5 |
Mol. Mass. | 411.236 |
SMILES | OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)c(c2)[N+]([O-])=O)C1 |
Structure |
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