| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 3 |
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| Ligand | BDBM50499634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1542814 (CHEMBL3742704) |
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| IC50 | >10000±n/a nM |
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| Citation |  Hobson, AD; Harris, CM; van der Kam, EL; Turner, SC; Abibi, A; Aguirre, AL; Bousquet, P; Kebede, T; Konopacki, DB; Gintant, G; Kim, Y; Larson, K; Maull, JW; Moore, NS; Shi, D; Shrestha, A; Tang, X; Zhang, P; Sarris, KK Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. J Med Chem58:9154-70 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 3 |
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| Name: | MAP kinase-activated protein kinase 3 |
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| Synonyms: | 3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 42991.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays. |
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| Residue: | 382 |
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| Sequence: | MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
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| BDBM50499634 |
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| n/a |
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| Name | BDBM50499634 |
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| Synonyms: | CHEMBL3741589 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17Cl2NO3 |
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| Mol. Mass. | 366.238 |
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| SMILES | OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1 |
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| Structure | 
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