| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM59087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1541949 (CHEMBL3743621) |
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| IC50 | 350±n/a nM |
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| Citation |  Manda, S; Sharma, S; Wani, A; Joshi, P; Kumar, V; Guru, SK; Bharate, SS; Bhushan, S; Vishwakarma, RA; Kumar, A; Bharate, SB Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. Eur J Med Chem107:1-11 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM59087 |
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| n/a |
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| Name | BDBM59087 |
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| Synonyms: | CHEMBL258765 | Fasca-plysi | Fascaplysin |
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| Type | Small organic molecule |
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| Emp. Form. | C18H11N2O |
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| Mol. Mass. | 271.2922 |
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| SMILES | O=C1c2ccccc2-[n+]2ccc3c([nH]c4ccccc34)c12 |
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| Structure | 
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