| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50049157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54109 (CHEMBL668439) |
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| IC50 | 1530±n/a nM |
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| Citation |  Tsukamoto, T; Kitazume, T; McGuire, JJ; Coward, JK Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate. J Med Chem39:66-72 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50049157 |
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| n/a |
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| Name | BDBM50049157 |
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| Synonyms: | 4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-2,2-difluoro-pentanedioic acid | CHEMBL423985 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20F2N8O5 |
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| Mol. Mass. | 490.4202 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CC(F)(F)C(O)=O)C(O)=O |
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| Structure | 
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